PRP Treatment is the significant of attention and it is an application for tissue repair and haemostasis during the healing process of ulcers and undermined wound surfaces.PRP is an autologous concentration of platelets in concentrated plasma. It is considered to be a rich source of autologous growth factors which appear to enhance angiogenesis, extracellular matrix remodelling, and cellular effects as cell proliferation and differentiation. Since then, it has been investigated and used in numerous fields of medicine, such as orthopedics, oral and maxillofacial surgery, plastic surgery and also dermatology. Recently, there have been little peer-reviewed studies investigating the clinical results of PRP applications as an alopecia treatment and no review articles regarding PRP's mechanism of action on hair follicle (HF) despite its possible promising results. Objectives of this article are to present PRP and its potent mechanism of action in promoting hair growth.
PRP is defined as a volume of the plasma fraction of autologous blood with an above baseline platelet concentration (usually more than 1,000,000 platelets/μL). PRP's regenerative potential depends on the levels of released. Alpha granules of platelets, which upon activation, are responsible for the initiation and maintenance of the healing response. PRP is known to carry more than 20 growth factors and other protein molecules, such as adhesion molecules, which interact to promote inflammation, cell proliferation, differentiation, and regeneration.
Here Main Growth Factors were stored in α-granules of platelets are platelet-derived growth factor (PDGF), transforming growth factor-b and vascular endothelial growth factor with their isoforms. They bind to their respective receptors, acting in tissue angiogenesis and stimulating the healing and growth of new organic structures. Growth of the Hair is an act in the bulge area of the follicle, where primitive stem cells of ectodermal origin are found, giving origin to epidermal cells and sebaceous glands. In matrix, germinative cells of origin are found at the dermal papilla (DP). Interaction between these two kinds of cells as well as with binding Growth Factors activate the proliferative phase of the hair, giving rise to the future follicular unit.
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